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KMID : 0371320010610020153
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Journal of the Korean Surgical Society
2001 Volume.61 No. 2 p.153 ~ p.157
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Expression of p27Kip1 Protein Associated with Poor Clinical Outcome in Human Gastric Cancer
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Bu Dong-Su
Han Se-Hwan
Bae Byung-Noe
Kim Ki-Whan
Kim Hong-Joo
Kim Young-Duck
Kim Hong-Yong
Park Kyeong-Mee
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Abstract
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Purpose
p27Kip1 protein is an inhibitor of cyclin-dependent kinases and is thought to be a potential prognostic indicator for numerous human cancers. We investigated the expression of p27Kip1 in gastric cancer in order to estimate its clinical utility.
Methods
Immunohistochemical assay for p27Kip1 protein was performed in 64 patients with primary gastric cancer. The correlation between p27Kip1 and clinical-biological parameters including patient survival was analyzed.
Results
p27Kip1 expression was suppressed in 40 (62.5%) of 64 gasr..EABS:
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KEYWORD
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